On May 14, 2025, the US Food and Drug Administration (FDA) announced the approval of telisotuzumab vedotin-tllv (EMRELIS™) to treat patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with high levels of c-Met protein who have been previously treated with a systemic therapy, such as immunotherapy or chemotherapy.  

This ADC, or antibody-drug conjugate, is the first approval of its kind. This ADC treatment is designed with two key elements.  

RET proteins are a type of receptor tyrosine kinase—an important group of signaling molecules in healthy cells. When RET proteins are turned “on” and “off” in healthy cells, they control the function of other proteins. This cascading effect allows the cells to manage important cellular functions such as cell growth through protein signaling pathways.  

Historically, approaches to treating lung cancer included surgery, radiation, and chemotherapy. The past decade ushered in a new era of treatments with targeted therapy and immunotherapy.

What Is Integrative Oncology? 

Integrative oncology is the use of complementary therapies alongside conventional lung cancer treatments like chemotherapy, targ

Surgery is a treatment option for early-stage lung cancer that involves removing all or part of a lung to treat a cancerous tumor. It is primarily an option for people with non-small cell lung cancer (NSCLC) staged at I, II, or IIIA. Surgery is rarely considered for tumors at stage IIIB or IV because those lung cancers have spread to other parts of the body.

The four-person panel, including John Heymach, MD, PhD, from MD Anderson Cancer Center, discuss the current FDA-approved targeted treatments for RET-positive lung cancer—selpercatinib (Retevmo) and pralsetinib (Gavreto). While these first-line treatments have proven helpful in treating RET-positive non-small cell lung cancer, the cancer cells can eventually become resistant to the treatment, which is guiding much of Dr. Heymach’s attention at the moment.

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Here we present the final video in our three-part series about how patients and researchers can work together to develop clinical trials.  

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We are pleased to continue our three-part series about how patients and researchers can work together to develop clinical trials.  

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Throughout 2024 we published blogs sharing scientific meeting recaps, educational content, personal stories, treatment news, and so much more. Below are the most popular articles we published in 2024. 

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Brain metastases (also called brain mets) develop when cancer from somewhere else in the body spreads to the brain.